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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (7): 730-733.

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Relation between modulation of the N-methyl-D-aspartate receptor and cyanide-induced neurotoxicity

WU Bo-La, ZHU Tong-Jun   

  1. Department of Pharmacology, Wenzhou Medical College, Wenzhou 325027, Zhejiang, China
  • Received:2004-06-01 Revised:2004-06-25 Online:2004-07-26 Published:2020-11-20

Abstract: Cyanide can activate the N-methyl-D-aspartate(NMDA) receptor by two approaches directly and indirectly.Firstly cyanide-induced depletion of energy is associated with the activation of NMDA receptors indirectly by increasing extracellular glutamate (Glu) and affecting cytosolic Ca2 +homeostatic mechanisms.Secondly most likely as a conditioner of the NMDA receptor, cyanide enhances NMDA receptors responses by modulating redox sites of cysteine residue located in the subunit NR1

Key words: N-methyl-D-aspartate ( NMDA) receptor, neuronal excitotoxicity, cyanide neurotoxicity, glutamate (Glu)

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