The synthesis and metabolism of neurosteroids and the effects on the nervous system

Abstract

Abstract: Neurosteroids exist in central and peripheral nervous system, independence of peripheral glands, including pregnenolone, progesterone, allopregnanolone,and dehydroepiandrosterone, etc.They can be synthesized in the nervous system from sterol or sterol precursors catalyzed by certain enzymes.They play roles by interacting with GABAA, NMDA orσreceptors, and have effects on memory, sleep, convulsion, cellular excitability, etc.

Key words: neurosteroids, pregnenolone, progesterone, allopregnanolone, dehydroepiandrosterone, nervous system

CLC Number:

R459.1

WANG Dan, LU Ying-Qing, YU Rong. The synthesis and metabolism of neurosteroids and the effects on the nervous system[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2004, 9(7): 725-729.

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