Abstract: AIM: To investigate the effects of Ginkgo biloba extract on rats with renal ischemia reperfusion injury and its protective mechanism was discussed.METHODS: A model of renal ischemia reperfusion injury was set up.34 SD rats were randomly divided into sham operated group (n=10), ischemia reperfusion group (n=12), and Ginkgo biloba extract injection group (n=12).The renal ischemic injury and neutrophil infiltrate in tissue stained with hematoxylin and eosin were observed.The expression of P-Selectin in kidney was evaluated by immunohistochemistry.RESULTS: As compared with sham operated group, some ischemic changes increased significantly in the renal tubular epithelial cells, P-selectin expression (P<0.01)and neutrophils in glomerular increased in ischemia reperfusion group (P<0.001).As compared with ischemia reperfusion group, some mild ischemic changes alleviated significantly in the renal tubular epithelial cells and P-selectin expression (P<0.01)and neutrophils in glomerular decreased in Ginkgo biloba extract injection group (P<0.001).CONCLUSION: The administration of Ginkgo biloba extract can alleviate rat renal ischemia reperfusion injury, and decrease P-selectin expression and neutrophils infiltration in glomerular.

Key words: Ginkgo biloba extract, P-selectin, ischemia reperfusion injury, kidney, neutrophil