Abstract: AIM: To observe the effects of naoyikang on the capability of learning and memory in Alzheimer's disease model mice.METHODS: The mice model was established by intraperitoneal injection of D-Gal and Na-NO₂, the capability of learning and memory was tested on mice by electrical maze and water maze, the levels of superoxide dismutase (SOD) and malondialdehyde (MDA) of brain tissues were assayed by biochemical methods, and the changes in ultrastructure were observed by Transmission Electron Microscope.RESULTS: The capability of learning and memory of model mice decreased and the level of SOD of model mice decreased and MDA increased.Compared with the madel group, they were obviously improved in low, middle and high doses (2.4, 7.2, 24 g·kg^-1·d^-1) of naoyikang group (P <0.01 or P <0.05), and the degeneration of mice cells was inhibited.CONCLUSION: Naoyikang can ameliorate the capability of learning and memory in AD model mice induced by D-Gal and NaNO₂.

Key words: Alzheimer's disease, animal model, naoyikang, learning and memory, superoxide dismutase, malondialdehyde