Effects of tetrahydrobiopterin on renal ischemia-reperfusion injury in rats

Abstract

Abstract: AIM: To investigate the effects and mechanisms of tetrahydrobiopterin (BH₄) on renal ischemia-reperfusion injury in rats.METHODS: The ischemia-reperfusion model was induced and 20 mg°kg^-1 BH₄ was orally administrated 1 h before the operation.NO, NOS activity, MPO activity and MDA and renal function were measured in order to assess the efficacy of BH₄. RESULTS: BH₄ ameliorated cNOS during the early period of reperfusion and increased the NO level in renal tissue which diminish inflammation responses and decrease the induction of iNOS.CONCLUSION: BH₄ can attenuate renal ischemia-reperfusion injury, and it may be related to ameliorating cNOS during the early period of reperfusion.

Key words: tetrahydrobiopterin, nitric oxide, renal, ischemia-reperfusion injury, rats

CLC Number:

R972.4

ZHANG Yan-qing, ZHANG Ying, WANG Shun-rong, LI Zhu-hua. Effects of tetrahydrobiopterin on renal ischemia-reperfusion injury in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(2): 172-175.

References

1 王新良, 黄善生.肾脏缺血再灌注损伤中肾小球的改变与 NO 的作用[J].国外医学:生理病理科学与临床分册, 2001;21:154-6
2 Higashi Y, Sasaki S, Nakagawa K, Fukuda Y, Matsuura H, Oshima T, et al.Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertansive individuals[J].Am J Hypertens, 2002;15:326-32
3 Fukuda Y, Teragawa H, Matsuda K, Yamagta T, Matsuura H, Chayama K.Terahydrobiopterin restores endothelial function in patients with hypercholesterolaemia[J].Heart, 2002;87:264-9
4 Shinozaki K, Nishio Y, Okamura T, Yoshida Y, Maegawa H, Kojima M, et al.Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats [J].Circulation, 2000;87:566-73
5 杨恒文, 曾琳, 杜晓兰, 刘媛, 廖维宏.肝缺血预处理对 NO、ET 和LBF 的影响[J].创伤外科杂志, 2001;3:266-8
6 Kakoki M, Hirata Y, Hayakawa H, Suzuki E, Nagata D, Tojo A, et al.Effects of tetrahydrobiopterin on endothelial dysfunction in rats with ischemic acute renal failure[J].J Am Soc Nephrol, 2000;11:301-9
7 谢晋良, 曹文露, 周成, 熊凤姣, 齐范.一氧化氮合酶在肾脏缺血预处理中的表达[J].中国现代医学杂志, 2002;12: 35-7
8 Panda K, Rosenfeld RJ, Ghosh S, Meade AL, Getzoff ED, Stuehr DJ.Distinct dimer interaction and regulation in nitric-oxide synthase types I, II, and III[J].J Biol Chem, 2002;277: 31020-30
9 Tiefenbacher CP.Tetrahydrobiopterin:a critical cofactor for eNOS and a strategy in the treatment of endothelial dysfunction [J].Am J Phy siol Heart Circ Phy siol, 2001;280:H2484-8
10 Vasquez-Vivar J, Kalyanaraman B, Martasek P.The role of tetrahydrobiopterin in superoxide generation from eNOS:enzymology and physiological implications[J].Free Radic Res, 2003;37:121-7
11 Shimizu S, Ishii M, Momose K, Yamamoto T.Role of tetrahydrobiopterin in the function of nitric oxide synthase, and its cytoprotective effect[J].Int J MolMed, 1998;2:533-40
12 Kojima S, Ona S, Iizuka I, Arai T, Mori H, Kubota K.Antioxidative activity of 5, 6, 7, 8-tetrahydrobiopterin and its inhibitory effect on paraquat-induced cell toxicity in cultured rat hepatocytes[J].Free Radic Res, 1995;23:419-30

[1]	WANG Fei, HANG Yongfu, WANG Wei. Influence of argumented renal clearance on teicoplannin serum concentrations in critical ill patients [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(9): 1043-1048.
[2]	LI Shixu, LI Linyun, WANG Xin, LI Ke, BIAN Hua. Effects of Ginkgo biloba extract on renal injury in rats with experimental renal failure through miR-145/FOXO1 axis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(7): 728-735.
[3]	WANG Donghui, JIANG Suwen, HU Airong, ZHU Bo, HE Zheyun, ZHANG Lukan, WANG Jialan, FAN Ying, LIN Ken . Mulberry exerts antioxidant stress effect in rats with nonalcoholic fatty liver disease [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(6): 609-616.
[4]	DANG Zilong, LIU Haiyang, ZHANG Yangfan, LIU Jinfeng, ZHANG Tianwei, LI Bin, GUO Hong, CHENG Wenyuan, XU Xiaohui, LI Yile, WEI Yuhui, WU Xin'an. Optimization strategy of antibiotic dosing regimen in intensive care unit patients with augmented renal clearance [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(5): 561-571.
[5]	MA Yue, MA Wangbo, ZHOU Zhihua, CHANG Jingwen, FAN Fangtian. Intervention of quercetin in glycolysis of renal interstitial fibroblasts against interstitial fibrosis mechanism [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(2): 121-129.
[6]	HENG Bingbing, YANG Danfeng, DAI Shuyang, SHANGGUAN Wangning. Propofol relieves the subcutaneous chloroquine-induced pruritus in rats via TRPV1 and CB1 receptors of spinal cord [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(10): 1101-1108.
[7]	XU Tao, ZHU Suyan, QIU Xiangjun, XU Ping. Population pharmacokinetics of teicoplanin in patients with renal insufficiency [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(9): 977-983.
[8]	ZHANG Wei, WANG Yingbin, CAO Lu, LIU Yan, ZHANG Li, LIU Jieting. Research progress of autophagy in intestinal ischemia-reperfusion injury [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(9): 1061-1066.
[9]	WU Lijun, Li Xin, CUI Lijuan, LI Xinxin, WANG Yan. Amelioration of nebivolol on renal interstitial fibrosis in UUO rats based on proteomic analysis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 729-738.
[10]	LIN Xueyan, LIN Zhihui, HUANG Huping. Effect of terlipressin on renal function in cirrhotic patients with esophageal gastric varices bleeding and normal baseline renal function [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 775-784.
[11]	WANG Xinli, XU Xiaqing, FANG Hanbing, GUO Yuzhong. Study of TPA on enhancing the anti-tumor effects of cisplatin and reducing its renal toxicity [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(5): 535-543.
[12]	LV Xingjiao, LENG Yufang, HAN Xiaoxia, HOU Xiaoyu, CAO Xuefen, Janvier NIBARUTA, LIU Yongqiang . Research progress of short-chain fatty acids in alleviating organ ischemia-reperfusion injury [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(2): 219-226.
[13]	WU Wei, CHEN Zheng, DU Zhen, QU Shuangquan. Vinpocetine improves the long-term cognitive function of infant rats induced by sevoflurane via Wnt/GSK3β/β-catenin signaling pathway [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(5): 539-545.
[14]	ZHANG Jianmin, LENG Yufang, LIU Xin, REN Yixing, SHI Yajing, CHEN Feng. Research progress on the mechanism of miRNA in intestinal ischemia-reperfusion injury [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(3): 332-340.
[15]	LU Yapeng, LIU Yang, HAO Wei, ZHONG Hailian, XIE Jianqin, LIU Jieting, WANG Yingbin. Research progress on the role of pyroptosis in intestinal ischemia-reperfusion injury [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2021, 26(12): 1437-1443.