Abstract: AIM: To study the effects and mechanisms of vinpocetine injection in treatment of mice with the transient ischemic attack (TIA).METHODS: TIA was induced by injection of peroxide in mice.Different doses of vinpocetine injection were injected every day. Lysophosphatidic acid (LPA) and phosphatidic acid (PA) were assayed.RESULTS: The stroke score of mice inject with vinpocetine injection (0.7 mg°kg^-1°d^-1) was 3.576±0.569, while the score of the control group was 7.090±0.696(P<0.05).Plasma LPA of mice with TIA were increased compared with the control group.These were 6.305±0.190 and 2.170±0.123 μmol°L^-1, respectively.After administration of vinpocetine injection, it decreased to 4.523±0.406 μmol°L^-1.Plasma PA of mice with TIA were increased compared with the control group.These were 9.100±0.185 and 3.801±0.257 U, respectively.After administration of vipocetine injection, it decreased to 6.972±0.247 U.CONCLUSION: The plasma LPA and PA lever changes with experimental TIA in mice.Vipocetine injection can take the beneficial effect on them.

Key words: vipocetine, transient ischemic attack, lysophosphatidic acid, phosphatidic acid