Abstract: AIM: To study protective effects of Salvia miltiorrhiza on bleomycin (BLM)-induced pulmo-nary fibrosis in mice. METHODS: Animal model with pulmonary fibrosis in SD mice was replicated by intratra-cheal injections of bleomycin and Salvia miltiorrhiza in-jection were given after replicated 7th day. Ratswere exe-cuted in 7th and 28th day, MDA, GSH andHYP in lung tissue bomogenate and the lung histopathological change were detected to investigate the effects of Salvia miltior-rhiza injection on lung fibrisis form in different stages. RESULTS: Salviae miltiorrhizae injection given after replicated first day restrained the increase of MDA and HYP, and decreased the GSH of lung tissue bomogenate, and lighten pathological lesion.Salvia miltiorrhiza injec-tion given after replicated the 7th day had no statistical difference between Salvia miltiorrhiza therapy groups and model group.CONCLUSION: Salvia miltiorrhiza injec-tion can prevent mice pulmonary fibrosis from and has no side effects on formative rat pulmonary fibrosis.

Key words: Salvia miltiorrhiza, bleomycetin, pul-monary fibrosis, mice, bleomycin