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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (12): 1336-1339.

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Experimental study on antipyretic, analgesic and anti-inflammatory actions of cinnamaldehyde

MA Yue-ying, LI Cang-hai1, LI Lang-fang, ZHO Bao-sheng, GUO Shu-ying, HUO Hai-ru   

  1. Tang Center for HerbalMedicine Research, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences,Beijing 100700, China;
    1Medical Experimental Center, China Academy of Chinese Medical Sciences, Beijing 100700, China
  • Received:2006-08-02 Revised:2006-12-05 Online:2006-12-26 Published:2020-11-06

Abstract: AIM: To observe the antipyretic-analgesic and anti-inflammatory effects of cinnamaldehyde.METHODS: Febrile model of rats was induced by injecting fresh yeast subcutaneously.The pain models were established by acetic acid and hot plate in mice.The mice inflammatory models were applied by dimethylbenzene(auricle smearmethod)and HAc-induced peritoneal capillary permeability, respectively.RESULTS: Cinnamaldehyde depressed the fervescence by yeast effectively in rats, inhibited the pain evidently caused by acetic acid and hot plate in mice.At the same time, it was found that the mouse' s ear edema induced by dimethylbenzene and the capillary permeability were significantly suppressed by cinnamaldehyde.CONCLUSION: Cinnamaldehyde has remarkable antipyretic-analgesic and anti-inflammatory effects.

Key words: cinnamaldehyde, pyretolysis, analgesia, anti-inflammation

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