DNA methylation and tumor disease

Abstract

Abstract: Abnormal methylation of DNA in certain genomic regions is a frequent epigenetic alteration that is involved in Human tumorigenesis and development .Vari- ous studies have shown that this aberrant DNA modifica- tion can be detected in body fluids of tumor patients, e . g .circulating blood , sputum , urine .So the evaluation of DNA methylation in these body fluids by methylaion de- tection methods can be utilized as a potential biomarker for early cancer detection and accurately clinical assess . This plays a significant role in cancer diagnosis and treat- ment .

Key words: DNA methylation , CpG island , epige- netics , DNA methyl-transferase , tumor diagnose

CLC Number:

R730 .49

WU Zhong-nan , ZHOU Xiang-jun , WANG Yong-xiang. DNA methylation and tumor disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(2): 131-135.

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