Abstract: AIM: To investigate the effect of SK Royaljelly R-1(SKR)on the innate immunity, humoral immunity, cell immunity in mice.Methods: Observe the effect of SKR on immunity function in mice, the phagocytotic rate and phagocytotic index, haemolysin in serum, plaque forming cell, and the proliferation of splenocyte following administration SKR for 15 days.Result: SK Royaljelly R-1 improved the formulation of serum haemolysin significantly (P<0.01), increased PFC and Il-2 production significantly (P<0.01), and stimulated the splenocyte proliferation stimulated by ConA of normal mice (P<0.01).Conclusion: The results suggeste SKR could potentiate the immunological function of normal mice.

Key words: Royaljelly, immunity, IgM, plaque forming cell, IL-2