Progress in inhibitory mechanism of somatostatin in the growth of human colonic carcinoma cells

Abstract

Abstract: Somatostatin(SS) is an inhibiting gut hormone that widely exists in central nervous system (CNS), gastrointestinal tract, pancreatic tissue. A lot of researches indicate the anticancer activity of somatostatin analogue. It was reported to suppress proliferation of endocrine tumors,especially some solid tumors in digestive system. This review summarizes the progress on mecha-nism of somatostatin analogue(SSTA) and its influences on colon cancer of in recent years.

Key words: somatostatin, somatostatin receptor, coionic neoplasms, signal transduction

CLC Number:

R735.3

LIU Li, WU Pei. Progress in inhibitory mechanism of somatostatin in the growth of human colonic carcinoma cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(12): 1344-1353.

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