Relationship between eIF3 subfamily and the development of tumor

Abstract

Abstract: eIF3 is the largest and most complex eukaryotic initiation factor in mammals, and it plays an important role in the regulation of translation .Some studies showed that the changes of levels of gene and protein expression of many subunits in eIF3 family are associated with the development, progression, and prognosis of human tumors. The relationship between eIF3 subfamily and the tumor development and progres-sion was reviewed in this article.

Key words: elF3, eukaryotic initiation factors, tu-mor

CLC Number:

R730

HAN Li-fang, LIU Zhao-qian. Relationship between eIF3 subfamily and the development of tumor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(10): 1195-1200.

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