Abstract: AIM: To study the characteristics of diabetic obese rats induced by streptozotocin (STZ) combined with hyperalimentation animal feeds and the therapeutic effect of sibutramine on diabetes obese rats.METHODS: Rats were intravenously injected with low dose (25 mg/kg) of STZ and fed with hyperalimentation animal feeds for 4 months to establish diabetic obese rat model.The diabetic obese rats were treated with sibutramine 4 mg/kg for 17 days and the body weight and food intake daily were measured.The glucose tolerance was measured at the 15th day.At the end of the treatment, the body weight, abdominal viscera fat and right soleus muscle, the levels of blood lipid, blood sugar, insulinum demeshed in serum were measured and the insulin resistance index (FIRI) were calculated.RESULTS: The body weight, abdominal viscera fat weight and the coefficient in model rats increased significantly, but thelinea obliqua tibiae coefficient decreased significantly.The blood-fasting glocose, insulin level increased significantly, and the carbohydrate tolerance abnormality and insulin resistance occurred.The serum triglyceride (TG) level increased and the high-density lipoprotein cholesterol (HDL-C) decreased significantly.Sibutramine reduced the body weight, visceral fat mass and coefficient, ameliorated hyperinsulinemia and insulin resistant, and decreased the serum TG level and increased HDL-C level as well. But it had not obviously affected the soleus muscle coefficient, blood glucose, cholesterol and LDL-C level, and carbohydrate tolerance.CONCLUSION: The diabetic obese rat model could be induced by STZ and hyperalimentation animal feeds and sibutramine has therapeutic effect on obese diabetes rats.

Key words: obesity, diabetes, sibutramine, rat