Effects of brain derived neurotrophic factor on ion channel

Abstract

Abstract: Brain derived neurotrophic factor ( BD-NF) is one of the family of neurotrophic factors (NTF) which plays an important role in the growth, develop-ment, differentiation, maintenance and regeneration of various types of neurons in the CNS and PNS .BDNF also can affect the resting membrane potential of neu-rons, nervous excitation and synaptic transmission .It plays a critical role in the induction of synaptic plastic-ity .Many of these effects of BDNF are mediated by its modulation of ion channel properties .Recent report have shown that BDNF not only acts as a modulation of ion channels following TrkB-mediated activation of in-tracellular second messenger cascades and protein phosphorylation, but can also directly opens a Na⁺ channel. Thus, in addition its role as a potent neuromodulator，BDNF emerges as an excitatory transmitter.

Key words: brain derived neurotrophic factor, lon channel, receptor, neuron

CLC Number:

R966

LI Guan-hua, FENG Ze-guo, ZHOU Jian-ping , WANG Hong. Effects of brain derived neurotrophic factor on ion channel[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(4): 463-467.

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