Comparison between S. miltiorrhiza Bunge Injection and S. przewalskii Maxim Injection on cerebral ischemia-reperfusion injury in rats

Abstract

Abstract: AIM: To compare the influence of S. miltiorrhiza Bunge Injection (SMBI) and S.przewalskii Maxim Injection (SPMI) on cerebral ischemia-reperfusion injury in rats.METHODS: Focal cerebral ischemia-reperfusion injury model was made with suture-occluded method.The levels of NOS and NO in serum and brain water content were measured.The neurological deficits of rats were observed after occluding middle cerebral artery for 45 min and reperfusion for 2 hours. RESULTS: After cerebral ischemia-reperfusion, the levels of NOS and NO in serum and brain water content increased significantly.SMBI and SPMI both effectively improve neural function, reduce hydrocephalus, and reduce the levels of NOS and NO in serum in rat models.CONCLUSION: These results suggested that SMBI and SPMI had obvious protective effect on cerebral ischemia-reperfusion injury.

Key words: S.miltiorrhizaBungeInjection(SMBI), S.przewalskiiMaximInjection(SPMI), cerebrqalischemia-reperfusion, NOS, NO, neurologicimpairmentscore, hydrocephalus, cerebrovascularpermeability

CLC Number:

R965.2

LUO Hui-ying, CHENG Ti-juan. Comparison between S. miltiorrhiza Bunge Injection and S. przewalskii Maxim Injection on cerebral ischemia-reperfusion injury in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(9): 972-975.

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