Research progress of Nampt Visfatin PBEF

Abstract

Abstract: Nicotinamide phosphoribosy ltransferase (Nampt)is the crucial rate-limiting enzyme of NAD biosynthesis, also known as pre-B cell colony-enhancing factor (PBEF) and visfatin.Recently, it has been found that Nampt/Visfatin/PBEF plays a role in many fields like NAD biosynthesis, metabolism and inflammatory response, as well as cell proliferation, differentiation and apoptosis.Nampt/Visfatin/PBEF might affect the development and prognosis of diseases such as type 2 diabetes, pulmonary diseases, malignant tumors and so on.This paper focuses on the physiological function and clinical significance of Nampt/Visfatin/PBEF.

Key words: nicotinamide phosphoribosyltransferase, pre-B cell colony enhancing factor, visfatin

CLC Number:

R969

SHENG Fei-feng, LIU Zhao-qian. Research progress of Nampt Visfatin PBEF[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(12): 1423-1427.

References

[1] Revollo JR, Grimm AA, Imai S.The regulation of nicotinamide adenine dinucleotide biosynthesis by Nampt PBEF visfatin in mammals[J].Curr Opin Gastroenterol, 2007, 23(2):164-170.
[2] Preiss J, Handler P.Enzymatic synthesis of nicotinamide mononucleotide[J].J Biol Chem, 1957, 225(2):759-770.
[3] Martin PR, Shea RJ, Mulks MH.Identification of a plasmid- encoded gene from Haemophilus ducreyi which confers NAD independence[J].J Bacteriol, 2001, 183(4):1168-1174.
[4] Samal B, Sun Y, Stearns G, et al.Cloning and characterization of the cDNA encoding a novel human pre-B-cell colony -enhancing factor[J].Mol Cell Biol, 1994, 14(2):1431-1437.
[5] Fukuhara A, Matsuda M, Nishizawa M, et al.Visfatin:a protein secreted by visceral fat that mimics the effects of insulin[J].Science, 2005, 307(5708):426-430.
[6] Mé nissier de Murcia J, Ricoul M, Tartier L, et al.Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse[J]. EMBO J, 2003, 22(9):2255-2263.
[7] Corda D, Di Girolamo M.Functional aspects of protein mono-ADP-ribosylation[J].EMBO J, 2003, 22(9):1953-1958.
[8] Lee HC.Physiological functions of cyclic ADP-ribose and NAADP as calcium messengers[J].Annu Rev Pharmacol Toxicol, 2001, 41:317-345.
[9] Lin SJ, Guarente L.Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease[J].Curr Opin Cell Biol, 2003, 15(2):241-246.
[10] Alghasham AA, Barakat YA.Serum visfatin and its relation to insulin resistance and inflammation in type 2 diabetic patients with and without macroangiopathy[J].Saudi Med J, 2008, 29(2):185-192.
[11] Zhu J, Schott M, Liu R, et al.Intensive glycemic control lowers plasma visfatin levels in patients with type 2 diabetes[J].Horm Metab Res, 2008, 40(11):801-805.
[12] Chen CC, Li TC, Li CI, et al.The relationship between visfatin levels and anthropometric and metabolic parameters:association with cholesterol levels in women[J].Metabolism, 2007, 56(9):1216-1220.
[13] Filippatos TD, Derdemezis CS, Kiortsis DN, et al.Increased plasma levels of visfatin pre-B cell colony-enhancing factor in obese and overweight patients with metabolic syndrome[J].J Endocrinol Invest, 2007, 30(4):323-326.
[14] Jia SH, Li Y, Parodo J, et al.Pre-B cell colony-enhancing factor inhibits neutrophil apoptosis in experimental inflammation and clinical sepsis[J].J Clin Invest, 2004, 113(9):1318-1327.
[15] Moschen AR, Kaser A, Enrich B, et al.Visfatin, an adipocytokine with proinflammatory and immunomodulating properties[J].J Immunol, 2007, 178(3):1748-1758.
[16] Zhang YY, Gottardo L, Thompson R, et al.A visfatin promoter polymorphism is associated with low-grade inflammation and type 2 diabetes[J].Obesity (Silver Spring), 2006, 14(12):2119-2126.
[17] Borradaile NM, Pickering JG.Nicotinamide phosphoribosyltransferase imparts human endothelial cells with extended replicative lifespan and enhanced angiogenic capacity in a high glucose environment[J].Aging Cell, 2009, 8(2): 100-112.
[18] Wang P, Xu TY, Guan YF, et al.Perivascular adipose tissue-derived visfatin is a vascular smooth muscle cell growth factor:role of nicotinamide mononucleotide[J]. Cardiovasc Res, 2009, 81(2):370-380.
[19] Adya R, Tan BK, Punn A, et al.Visfatin induces human endothelial VEGF and MMP-2 9 production via MAPK and PI3K Akt signalling pathways:novel insights into visfatininduced angiogenesis[J].Cardiovasc Res, 2008, 78(2): 356-365.
[20] Skokowa J, Lan D, Thakur BK, et al.NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway[J].Nat Med, 2009, 15(2):151-158.
[21] Van der Veer E, Ho C, O'Neil C, et al.Extension of human cell lifespan by nicotinamide[J].J Biol Chem, 2007, 282(15):10841-10845.
[22] Li Y, Zhang Y, Dorweiler B, et al.Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin- 6 STAT3 signaling mechanism[J].J Biol Chem, 2008, 283(50):34833-34843.
[23] Rongvaux A, Galli M, Denanglaire S, et al.Nicotinamide phosphoribosyl transferase pre-B cell colony-enhancing factor visfatin is required for lymphocyte development and cellular resistance to genotoxic stress[J].J Immunol, 2008, 181(7):4685-4695.
[24] Fukuhara A, Matsuda M, Nishizawa M, et al.Retraction[J].Science, 2007, 318(5850):565.
[25] Revollo JR, Kö rner A, Mills KF, et al.Nampt PBEF visfatin regulates insulin secretion in β cells as a systemic NAD biosynthetic enzyme[J].Cell Metab, 2007, 6(5): 363-375.
[26] Bailey SD, Loredo-Osti JC, Lepage P, et al.Common polymorphisms in the promoter of the visfatin gene (PBEF1)influence plasma insulin levels in a French-Canadian population[J].Diabetes, 2006, 55(10):2896-2902.
[27] Ramsey KM, Mills KF, Satoh A, et al.Age-associated loss of Sirt1-mediated enhancement of glucose stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO)mice[J].Aging Cell, 2008, 7(1):78-88.
[28] Kamp R, Sun X, Garcia JG.Making genomics functional: deciphering the genetics of acute lung injury[J].Proc Am Thorac Soc, 2008, 5(3):348-353.
[29] Hong SB, Huang Y, Moreno-Vinasco L, et al.Essential role of pre-B-cell colony enhancing factor in ventilator-induced lung injury[J].Am J Respir Crit Care Med, 2008, 178(6):605-617.
[30] Ye SQ, Zhang LQ, Adyshev D, et al.Pre-B-cell-colonyenhancing factor is critically involved in thrombin - induced lung endothelial cell barrier dysregulation[J].Microvasc Res, 2005, 70(3):142-151.
[31] Li H, Liu P, Cepeda J, et al.Augmentation of pulmonary epithelial cell IL-8 expression and permeability by pre-Bcell colony enhancing factor[J].J Inflamm (Lond), 2008, 5:15.
[32] Garcia JG, Moreno Vinasco L.Genomic insights into acute inflammatory lung injury[J].Am J Physiol Lung CellMol Physiol, 2006, 291(6):1113-1117.
[33] Ye SQ, Simon BA, Maloney JP, et al.Pre-B-cell colonyenhancing factor as a potential novel biomarker in acute lung injury[J].Am J Respir Crit Care Med, 2005, 171(4):361-370.
[34] Nahimana A, Attinger A, Aubry D, et al.The NAD biosynthesis inhibitor APO866 has potent antitumor activity against hematologic malignancies[J].Blood, 2009, 113(14):3276-3286.
[35] Eisele L, Klein-Hitpass L, Chatzimanolis N, et al.Differential expression of drug-resistance-related genes between sensitive and resistant blasts in acute myeloid leukemia[J].Acta Haematol, 2007, 117(1):8-15.
[36] HasmannM, Schemainda I.FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis[J].Cancer Res, 2003, 63(21):7436-7442.
[37] Muruganandham M, Alfieri AA, Matei C, et al.Metabolic signatures associated with a NAD synthesis inhibitor-induced tumor apoptosis identified by 1H-decoupled-31P magnetic resonance spectroscopy[J].Clin Cancer Res, 2005, 11(9):3503-3513.