Influence of creatinine clearance on serum methotrexate concentration in high-dose methotrexate therapy

Abstract

Abstract: AIM: To study the influence of creatinine clearance on serum methotrexate(MTX)concentration in high-dose methotrexate (HDMTX)therapy. METHODS: The data was collected from 44 children who were diagnosed of acute lymphocytic leukemia (ALL)or non-Hodgkin lymphoma (NHL), and were administered with 106 doses of HDMTX from Feb, 2006 to May, 2008.The association between creatinine clearance and serum methotrexate concentration at 24 and 42 h were retrospectively analyzed, by SPSS 12.0 format. RESULTS: There was a significant correlation between creatinine clearance and 24 h serum methotrexate concentration (P<0.05).while was no significant correlation between creatinine clearance and 42 h serum methotrexate concentration(P >0.05). CONCLUSION: Creatinine clearance can be related with 24 h serum methotrexate concentration, and can be referenced in estimating 24 h serum methotrexate concentration.

Key words: chemotherapy, high-dose methotrexate therapy, creatinine clearance, serum concentrati

CLC Number:

R969

LIN Xiao-wen, SHAO Hong, NIE Xiao-yan, SUN Ying-qi, ZHANG Le-ping, LI Yu-zhen, GU Jian. Influence of creatinine clearance on serum methotrexate concentration in high-dose methotrexate therapy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(3): 319-322.

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