Distribution of inosine triphosphate pyrophosphohydrolase activity in Han Chinese

Abstract

Abstract: AIM: To study the distribution of inosine triphosphate pyrophosphatase (ITPA) activity in Han Chinese.METHODS: The erythrocyte ITPA activity was detected in healthy Han Chinese by HPLC assay (n=402).RESULTS: There was no significant difference in the mean ITPA activity between male and female of Han Chinese or among different blood types(P>0.05) , a bimodal distribution of ITPA activity was found and the frequency of the ITPA deficiency was 27.6 % in Han Chinese.Furthermore, 6cases with ITPA activity deficiency were found, accounting for 1.47 % of total healthy recipients.CONCLUSION: The distribution of erythrocyte ITPA activity shows a bimodal distribution in Han Chinese.

Key words: inosine triphosphate pyrophosphatase, Han Chinese, activity

CLC Number:

R969

LI Wei-liang, XING Hua-wen, WU Xiao-chun, LI Qing, XIONG Lei. Distribution of inosine triphosphate pyrophosphohydrolase activity in Han Chinese[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 426-431.

References

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