DPHDevelopment of the genetic polymorphism study on organic cation transporters

Abstract

Abstract: Various kinds of transporters exist in human organs, such as liver, kidney and intestine.The transport of cationic substrates which include endogenous metabolites, exotic substance, and drugs was mainly executed by different organic cation transporters (OCTs).In this article the genetic polymorphisms and their influences on OCTs funtions were mainly reviewed.Meanwhile, the recent findings of OCTs polymorphism influences on pharmacodynamics and pharmacokinetics value of several clinical widely used drugs were also included in this review.

Key words: organic cation transporter, genetic polymorphism, pharmacokinetics

CLC Number:

R969

HAN Lin-zhi, ZHOU Hong-hao. DPHDevelopment of the genetic polymorphism study on organic cation transporters[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 460-464.

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