Application of imaging new techniques in experimental porcine pulmonary embolism model

Abstract

Abstract: Pulmonary embolism is a common acute cardiovascular disease with pulmonary artery and its embranchment blocked by endogenous or extraneous embolus.Usually, pulmonary embolism happens suddenly and has a high mutilation rate, so it is a big threat to human health, but the clinical and basic researches on pulmonary embolism are very limited.Imaging new techniques such as noninvasive spiral CT angiography (CTA ) , magnetic resonance angiography (MRA) , magnetic resonance (MR) perfusion, ventilation imaging , and real-time magnetic resonance imaging are developed recently and widely applied in porcine pulmonary embolism model.This paper briefly introduced the application of MR imaging in porcine pulmonary embolism model, including magnetic resonance imaging of fibrin-specific contrast agent in porcine pulmonary embolism model induced by human thromb, the comparision of CTA, MRA, real time magnetic resonance imaging in porcine pulmonary embolism model, the feasibility for the assessment of lung function in porcine pulmonary embolism model combining with MR perfusion, angiography and 3He ventilation imaging, the comparision on pulmonary ventilation perfusion CT and planar imaging in porcine pulmonary embolism model.The above-mentioned methods are useful to carry out the research of pulmonary embolism base drug and antipulmonary embolism drug.

Key words: magnetic resonance imaging, pulmonary embolism, hyperpolarized gas, animal model, fibrin-specific contrast agent

CLC Number:

R965.1

QIAN Bo-chu, SHI Hong, ZHENG Xiao-liang. Application of imaging new techniques in experimental porcine pulmonary embolism model[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 475-480.

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