Abstract: AIM: To observe the effects of short-term treatment of rosuvastatin on soluble E-selectin (sE-selectin) and P -selectin (sP-selectin) in patients with congestive heart failure(CHF). METHODS: 70 patients with CHF were randomly divided into conventional treatment group and intervention group, the conventional treatment group received placebo and the intervention group received rosuvastain 10 mg /n for 4 weeks. The levels of sE-selectin and sP-selectin were measured before and after treatment by ELISA. RESULTS: The levels of sE-selectin and sP-selectin in serum of patients with heart function class Ⅳ were significantly higher than those in patients with heart function classⅡand Ⅲ(P<0.01),but there was no significant difference between classⅡand Ⅲ (P>0.05).The levels of sE-selectin and sP-selectin in two groups were significantly decreased after treatment (P<0.05 or P<0.01), compared with the conventional treatment group, only the sE-selectin level was significantly decreased (P<0.05). CONCLUSION: The levels of sE-selectin and sP-selectin are significantly increased along with heart function deterioration.The level of sE-selectin is decreased with short-term rosuvastatin treatment.

Key words: Chronic heart failure, Rosuvastatin, sE-selectin and sP-selectin