Abstract: AIM: To investigate epidemiology and drug resistance associated with bacterial infection during early postoperative period after liver transplantation in the purpose of prevention and treatment. METHODS: Altogether 163 recipients of liver transplantation admitted from Apr.2004 to Dec.2009 in Nanfang Hospital were studied retrospectively and identified the bacterial and drug resistance. RESULTS: Bacterial infections occurred in 86 cases(52.7%)and 166 strains separated from various specimens.The main sites for pathogens were respiratory tract(68.2%), then blood(9.6%) and urine(8.4%). Main infections developed in the first month, especial in the front two weeks (81.9%). The strains bacteria included 76G^- strains (46.2%),68 G⁺ strains (39.3%) and 24 fungi strains(14.5%). The most commom were strains Acinetobacter Baumannii, Staphylococcus haemolysis, Klebsiella pneumoniae, Staphylococcus aureus, Bacillus coli (53.2%). There were 46 patients suffered from mixed bacterial infection. Most of the G^- bacteria were sensitive to carbapenems; G⁺ bacteria were sensitive to aminoglycosides and oxazolinones. CONCLUSION: The infective complications are common in patients with live transplantation an the early stage, it is important to identify the bacteria and drug resistance for the purpose of prophylaxis and treatments.

Key words: Liver transplantation, Bacterial infection, Epidemiology, Drug resistance, Prophylaxis