Preclinical advances in the abnormal expression and its activity of isoenzyme of superoxide dismutase

Abstract

Abstract: The expression and activity of isoenzyme of superoxide dismutase (Cu, Zn-SOD, Mn-SOD and EC-SOD) are very complicated. The different pathogenesis or physiology could lead to the change of their expression and activity in the different tissues or organs. And the amount and activity of isoenzyme of superoxide dismutase changes correspondingly. The reports on the abnormal expression and activity of isoenzyme of superoxide dismutasethe were rarely seen in domestic researches. This paper reviewed the preclinical reports on the enzymes. It would provide evidences for the diagnosis and therapy of the disease, the research of new drugs and the research of anti-oxide and anti-apoptosis.

Key words: Superoxide dismutase, Isoenzyme, Anti-oxide, Anti-apoptosis

CLC Number:

R363.22

WANG Zhan-qing, WANG Jin-ping, LIU Jing. Preclinical advances in the abnormal expression and its activity of isoenzyme of superoxide dismutase[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(10): 1195-1200.

References

[1] 曹红卫, 郭毅斌, 魏利召, 等. 青蒿素对脓毒症大鼠肝脏脂质过氧化损伤的影响[J]. 中国临床药理学与治疗学, 2006, 11(8):911-914.
[2] Bostwick DG, Alexander EE, Singh R, et al. An-tioxidant enzyme expression and reactive oxygen species damage in prostatic intraepithelial neoplasia and cancer [J]. Cancer, 2000, 89(1): 123-134.
[3] 韦薇, 李瑗, 苏建家, 等. 铜锌-超氧化物歧化酶在肝癌组织中的异常表达及意义[J]. 肿瘤, 2006, 26(2): 123-126.
[4] Quiros I, Sainz RM, Hevia D, et al. Upregulation of manganese superoxide dismutase(SOD2) is a common pathway for neuroendocrine differentiation in prostate cancer cells[J]. Int J Cancer, 2009, 125(7): 1497-1504.
[5] Kliment CR, Suliman HB, Tobolewski JM, et al. Extracellular superoxide dismutase regulates cardiac function and fibrosis[J]. Mol Cell Cardiol, 2009, 47(5): 730-742.
[6] Xia Z, Guo Z,Nagareddy PR, et al. Antioxidant N-acetylcysteine restores myocardial Mn-SOD activity and attenuates myocardial dysfunction in diabetic rats [J]. Eur J Pharmacol, 2006, 544(1/2/3): 118-125.
[7] Sadi G, Guray T. Gene expressions of Mn-SOD and GPx-1 in streptozotocin-induced diabetes: effect of antioxidants[J]. Mol Cell Biochem, 2009, 327(1/2): 127-134.
[8] 王占庆,王金萍,许景峰. 硝酸异山梨酯对大鼠心肌后期预适应的诱导作用[J]. 中国临床药理学与治疗学, 2006, 11(12):1385-1388.
[9] Scorziello A, Santillo M, Adornetto A, et al. NO-induced neuroprotection in ischemic preconditioning stimulates mitochondrial Mn-SOD activity and expression via Ras/ERK1/2 pathway [J]. J Neuro chem, 2007, 103(4): 1472-1480.
[10] Jan H, Olli L, Matias I, et al. Extracellular superoxide dismutase accelerates endothelial recovery and inhibits in-stent restenosis in stented atherosclerotic watanabe heritable hyperlipidemic rabbit aorta[J]. J Am Coll Cardiol, 2007, 50(23): 2249-2253.
[11] Andrea M,Vincent JW, Russell KA, et al. SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy [J]. Exp Neurol,2007, 208(2): 216-227.
[12] Wanida T, Kittisak S, James AD, et al. 17 β-Estradiol reduces nitrotyrosine immunoreactivity and increases SOD1 and SOD2 immunoreactivity in nigral neurons in male mice following MPTP insult [J]. Brain Res, 2007, 1164: 24-31.
[13] Kouhei H, Manabu H, Yutaka I, et al. Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice[J]. Am J Pathol, 2008, 172(5): 1325-1331.
[14] Izuta H, Chikaraishi Y, Adachi T, et al. Extracellular SOD and VEGF are increased in vitreous bodies from proliferative diabetic retinopathy patients[J]. Mol Vis, 2009, 15: 2663-2672.
[15] Doonan F, Wallace DM, O'Driscoll C, et al. Rosiglitazone acts as a neuroprotectant in retinal cells via up-regulation of sestrin-1 and SOD-2[J]. J Neuro chem,2009, 109(2): 631-643.
[16] Massaad CA, Washington TM, Pautler RG, et al. Overexpression of SOD-2 reduces hippocampal superoxide and prevents memory deficits in a mouse model of Alzheimer's disease[J]. Proc Natl Acad Sci USA, 2009, 106(32): 13576-13581.
[17] Maria CG, Heinrich EL, Ulf L, et al. Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air A potential mechanism underlying adult respiratory distress syndrome[J]. Am J Pathol, 2008,173(4): 915-926.
[18] Ueda J, Alexander ME, Crapo JD et al. Age-associated increase in oxidative damage and down-regulation of extracellular superoxide dismutase(EC-SOD) in endotoxin mediated acute lung injury[J]. Shock, 2006, 25(6): 68-69.
[19] Kravcukova P, Danielisova V, Nemethova M, et al. Transient forebrain ischemia impact on lymphocyte DNA damage, glutamic acid level, and SOD activity in blood[J]. Cell Mol Neurobiol,2009, 29(6/7): 887-894.
[20] Combelles CM, Holick EA, Paolella LJ, et al. Profiling of superoxide dismutase isoenzymes in compartments of the developing bovine antral follicles[J]. Reproduction, 2010, 139(5): 871-881.
[21] Liu SH, Huang JP, Lee RK, et al. Paracrine factors from human placental multipotent mesenchymal stromal cells protect endothelium from oxidative injury via STAT3 and manganese superoxide dismutase activation[J]. Biol Reprod,2010, 82(5):905-913.
[22] KamiyaT, Hara H, Yamada H, et al. Cobalt chlorid decreases EC-SOD expression through intracellular ROS generation and p38-MAPK pathways in COS7 cells[J]. Free Radic Res,2008, 42(11/12): 949-956.
[23] Peixoto EB, Pessoa BS, Biswas SK, et al. Antioxidant SOD mimetic prevents NADPH oxidase-induced oxidative stress and renal damage in the early stage of experimental diabetes and hypertension[J]. Am J Nephrol, 2009,29(4): 309-318.
[24] Na K, Kim KE, Park ST. EC-SOD suppresses contact hypersensitivity in mouse skin by impairing langerhans cell migration[J]. J Invest Dermatol, 2007, 127(8): 1930-1937.
[25] Murakami K, Inagaki J, Saito M, et al. Skin atrophy in cytoplasmic SOD-deficient mice and its complete recovery using a vitamin C derivative[J]. Biochem Biophys Res Commun, 2009, 382(2): 457-461.