Abstract: AIM: To explore the effects of panax notoginseno sides (PNS) on bone histomor phometry in rats with hyperlipidemia-inducedo steoporosis. METHODS: Thirty 3-month-old Sprague-Daw ley rats were randomly divided into three groups with 10 per group as follows. Control group was intrag astrically given distilled water at the do se of 5 mL ·kg^-1,d^-1 for 20 weeks ;Model group was intragast rically given lipid emulsion at the do se of 5 mL, kg ^-1,d^-1 for 20 weeks ;PNS preventing group was intragastrically given lipid emulsion at the dose of 5 mL ·kg^-1 ·d^-1 in the morning and PNS at the do se of 5 mL ·kg^-1 ·d^-1 at afternoon for 20 weeks.At the end of the experiment, the right longitudinal proximal tibial metaphy seal parameters of rats were performed undecalcifiedly and used for bone histomo rphometry analysis. And the blood serum contents of FFA, TG, TC, HDL-C and LDL-C were measured by biochemical analy sis. RESULTS: Compared with model group, the blood serum contents of FFA, TC and LDL-C were decreased and HDL-C was increased significantly (P<0.01), the PTM cancellous bone of %Tb. Ar, Tb. Th and Tb.N were increased (P<0.01) and Tb.Sp was decreased significantly (P<0.01).The dynamic parameters in cancellous bone of %L.Pm and bone format ion rate (BFR/BS, BFR/BV) were increased(P<0.05). CONCLUSION: Long-term gastric perfusion of lipid emulsion could induce hyperlipidemia-induced osteoporosis, and PNS could partly prevent it.

Key words: Panax notog inseno sides, Osteoporosis, Hype rlipidemia, Bone histomorphometry