Abstract: AIM: To investigate the expressions of BAG-1 and NF-κB P65 in the multiple my eloma (MM) and approach the effects of BAG-1 and NF-κB P65 in the pathogenesi s of MM and their clinical sig nificance, which would be useful tofind a theo retical basis for thet reatment of MM. METHODS: The pat ients diag no sed MM in Yiji shan ho spital of wannan medical college from 2006.10 to 2008.10 as the experimental group, w hi le the bo net rauma patients selected as the co nt ro l gro up.The mononuclearcells of bone marrow in the patient swere ext racted and the BAG-1and NF-κB P65 mRNA RT-PCR were detected. RESULTS: The expression of BAG-1 mRNA (71.4 %) in the MM patients was hig her than that in the control group(P=0.007).The expre ssion of NF-κB P65 mRNA (75.0 %) in the MM patients was hig her than that in the cont rol gro up(P =0.004).There was a positive correlation between the BAG-1 and NF-κB P65 mRNA. The tumo rload was high in the MM patients with overexpression of BAG-1 and NF-κB P65, which was ralated to a number of clinical pa rameters indexes.BAG-1 and NF-κB P65 we re po sitive expressed of MM tumor load, relatived with anumbe r of clinical indicato rs. CONCLUSION: The expressions of BAG-1 and NF-κB P65 in MM are high, there are no dif ference betw een the experimental group and control group.BAG-1and NF-κB P65 were related to a number of clinical indexes.BAG-1 and NF-κB P65 may be involved in the occurrence and the development of disease, and they can be used as one of the prog no sis indexes.

Key words: BAG-1, NF-κB P65, Multiple my eloma, RT-PCR