Effects of acid-sensing ion channels 3 subunit  in arthritis pain

Abstract

Abstract: Pain-related acid-sensing ion channels 3 (ASIC3), the most sensitive acceptor to such a pH change, has been shown to be predominantly expressed in the peripheral nervous system. Over recent years, there has been increased evidence that ASIC3 may lead to the pathogenesis of chronic inflammatory pain diseases because that it is predominantly expressed in dorsal root ganglia (DRG) neurons making it a good candidate for a pain sensor. It has been shown that increased expression of ASIC3 mRNA and protein was found in DRG of rodents with inflamed joints and ASIC3 gene knock-out mice (ASIC3-/-) exhibited no enhanced hyperalgesia in inflamed joint. These findings suggest that under the physiological or pathological circumstance, ASIC3 have an important biological effect on the sensor information, especially pain transmission of the spinal cord level, which might be a promising therapeutic target for arthritis pain. In this study, we will briefly discuss the biological features of ASIC3 and summarize recent advances on the role of ASIC3 in the arthritis and during the course of its treatment.

Key words: ASIC3, Inflammation, Pain, Hyperalgesia, DRG, Therapeutic target

CLC Number:

R962

LI Xia, YUAN Feng-Lai , CHEN Fei-Hu, ZHAO Yi-qing, LU Wei-Guo, HU Wei, ZHANG Teng-yue, WU Fan-rong. Effects of acid-sensing ion channels 3 subunit in arthritis pain[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(9): 1064-1068.

References

[1] Yoon E, Doherty JB. Arthritis pain[J]. J Gerontol Soc Work, 2008, 50 (Suppl 1):79-103.
[2] Shutty MS Jr, Cundiff G, De Good DE. Pain complaint and the weather: weather sensitivity and symptom complaints in chronic pain patients[J]. Pain, 1992, 49(2):199-204.
[3] Saggini R, Zoppi M, Vecchiet F, et al. Comparison of electromotive drug administration with ketorolac or with placebo in patients with pain from rheumatic disease: a double-masked study[J]. Clin Ther, 1996, 18(6):1169-1174.
[4] Mackey S. Mechanisms of inflammatory pain: therapeutic implications[J]. J Clin Rheumatol, 2004, 10(3):S5-S11.
[5] Ugawa S,Ueda T,Ishida Y,et al.Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors[J]. J Clin Invest, 2002, 110(8):1185-1190.
[6] 袁凤来, 陈飞虎, 黄学应, 等. 酸敏感离子通道在大鼠佐剂性关节炎关节软骨中的表达[J]. 中华风湿病学杂志,2008, 12(5):321-324.
[7] 袁凤来, 陈飞虎, 陆伟国, 等. 酸敏感离子通道阻断剂amiloride对佐剂性关节炎大鼠关节软骨损伤的影响[J]. 中国药理学通报,2009, 25(7):895-900.
[8] Lingueglia E. Acid-sensing ion channels in sensory perception[J]. J Biol Chem, 2007, 282(24):17325-17329.
[9] 陈飞虎, 袁凤来, 李霞, 等. 常用类风湿性关节炎药物对AA大鼠关节软骨细胞酸敏感离子通道的表达影响及作用[J]. 中国临床药理学与治疗学, 2008, 13(2):131-137.
[10] Yuan FL, Chen FH, Lu WG, et al. Acid-sensing ion channel 1a mediates acid-induced increases in intracellular calcium in rat articular chondrocytes[J]. Mol Cell Biochem, 2010, 340(1):153-159.
[11] Hattori T, Chen J, Harding AM, et al. Acid-sensing ion channels 2a and 3 heteromultimerize to form pH-sensitive channels in mouse cardiac dorsal root ganglia neurons[J]. Circ Res, 2009, 105(3):279-286.
[12] Hermanstyne TO, Markowitz K, Fan L, et al. Mechanotransducers in rat pulpal afferents[J]. J Dent Res, 2008, 87(9):834-838.
[13] Nagae M, Hiraga T, Wakabayashi H, et al. Osteoclasts play a part in pain due to the inflammation adjacent to bone[J]. Bone, 2006, 39(5):1107-1115.
[14] Ikeuchi M, Kolker SJ, Burnes LA, et al. Role of ASIC3 in the primary and secondary hyperalgesia produced by joint inflammation in mice[J]. Pain, 2008, 137(3):662-669.
[15] Waldmann R, Lazdunski M.H(+)-gated cation channels: neuronal acid sensors in the NaC/DEG family of ion channels[J]. Curr Opin Neurobiol, 1998, 8(3):418-424.
[16] Krishtal OA, Pidoplichko VI. A receptor for protons in the nerve cell membrane[J]. Neuroscience, 1980, 5(12):2325-2327.
[17] 袁凤来, 陈飞虎, 陆伟国, 等. 酸敏感离子通道在非神经组织中的功能研究[J]. 中国药理学通报, 2010, 26(2):147-151.
[18] 崔琳, 杨日芳, 郑建全, 等. 酸敏感离子通道抑制剂的研究进展[J]. 中国药物化学杂志, 2006, 16(2):114-121.
[19] Diochot S, Baron A, Rash LD, et al. A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons[J]. EMBO J, 2004, 23(7):1516-1525.
[20] Sucher NJ, Lipton SA, Dreyer EB. Molecular basis of glutamate toxicity in retinal ganglion cells[J]. Vision Res, 1997, 37(24):3483-3493.
[21] Sugiura T, Kasai M, Katsuya H, et al. Thermal properties of acid-induced depolarization in cultured rat small primary afferent neurons[J]. Neurosci Lett, 2003, 350(2):109-112.
[22] Dube GR, Lehto SG, Breese NM, et al. Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels[J]. Pain, 2005, 117(1/2):88-96.
[23] Voilley N, de Weille J, Mamet J, et al. Nonsteroid antiinflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptors[J]. J Neurosci, 2001, 21(20):8026-8033.
[24] Chen CC, Zimmer A, Sun WH, et al. A role for ASIC3 in the modulation of high-intensity pain stimuli[J]. Proc Natl Acad Sci USA, 2007, 99(13):8992-8997.
[25] Deval E, Noel J, Lay N, et al. ASIC3, a sensor of acidic and primary inflammatory pain[J]. EMBO J, 2008, 27(22):3047-3055.
[26] Babinski K, Le KT, Seguela P, et al. Molecular cloning and regional distribution of a human proton receptor subunit with biphasic functional properties[J]. J Neurochem, 1999, 72(1):51-57.
[27] Mogil JS, Breese NM, Witty MF, et al. Transgenic expression of a dominant-negative ASIC3 subunit leads to increased sensitivity to mechanical and inflammatory stimuli[J]. J Neurosci, 2005, 25(43):9893-9901.
[28] Yen YT, Tu PH, Chen CJ, et al. Role of acid-sensing ion channel 3 in sub-acute-phase inflammation[J]. Mol Pain, 2009, 7(5):1.
[29] Kuduk SD, Chang RK, Wai JM, et al. Amidine derived inhibitors of acid-sensing ion channel-3 (ASIC3)[J]. Bioorg Med Chem Lett, 2009, 19(15):4059-4063.
[30] Yuan FL, Chen FH, Lu WG, et al. Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis[J]. Mol Biol Rep, 2010, 37(7):3233-3238.

Effects of acid-sensing ion channels 3 subunit in arthritis pain

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments

[1]	LIAO Mengling, WANG Yan, LUO Jing, WANG Nuoyan, HUA Ling, ZHANG Yu, DENG Fei, YUAN Yue, ZHOU Jun, ZHOU Hong. Molecular mechanism of artesunate attenuates the release of proinflammatory cytokines from macrophages [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(9): 969-978.
[2]	WANG Anjing, WANG Yaya, LIANG Xuan, YAN Yajie, SU Jing, LI Caidong. Research progress on mechanisms and therapeutic drugs of peroxisome proliferator-activated receptor in treatment of cholestatic liver disease [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(7): 796-808.
[3]	ZHAO Lingzhi, HE Yanjun, XIE Jianqin, YOU Chongge. Research progress on therapeutic role of recombinant human soluble thrombomodulin in atherosclerosis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(7): 832-840.
[4]	ZHAO Lu, LI Fuyong, WEN Binhong, LI Daowei. Effects of stains on hyperlipidemia and pain relieve of patients with chronic migraine [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2023, 28(6): 671-675.
[5]	YANG Li, BAI Huhu, HE Shasha, JIN Yue, LIU Chengsong. Tyrosine phosphorylation of TRPM3 ion channel mediates diabetes-induced heat hyperalgesia [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(9): 971-976.
[6]	Qin LiYang. Effects of rapamycin intervention during pregnancy on cognitive function of autism model in rat offspring [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(8): 841-847.
[7]	LIANG Hongyu, ZHANG Hailin, YIN Huanxin, CHEN Fan, LU Junlin, ZHU Caihong, HU Wei, ZHOU Renpeng. Effects of 2-APB in skin wound healing in mice through down-regulation of TRPM7 [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 747-753.
[8]	JIA Tao, TENG Jinliang. New narcotic analgesics: esketamine [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(7): 834-840.
[9]	MAO Shuying, JIN Wei, FU Sisi, LIU Keanqi, ZHOU Zhihao, WANG Guangji, LIANG Yan. Oral lienal peptides improve ammonia-induced coughing and inflammation in mice [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 601-607.
[10]	JIN Yiyi, ZHOU Keting, YANG Chengcheng, XU Ping, ZHU Suyan. Osthole attenuates diabetes-induced renal injury by regulating NF-κB and p38/MAPK pathway mediated inflammatory responses [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 622-631.
[11]	SHEN Yanping, YIN Lijun, ZHUANG Wenming, YAN Haiya. Effective dose of esketamine for prevention on propofol injection pain in painless abortion [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(6): 660-664.
[12]	CHANG Shufu . Progress of medical treatment of coronary heart disease [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(4): 405-408.
[13]	WEI Jifang, YUE Hongmei, LIU Nanyu, SONG Peipei, XIE Yingying, WANG Jiaqi, WEI Yaqian. Research progress on the relationship between thyroid hormone and idiopathic pulmonary fibrosis [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(3): 307-313.
[14]	CHEN Yu, GU Bing, LI Huanan. Modulating gut miocrobiota: a new strategy in the treatment of gout [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(11): 1307-1314.
[15]	CHEN Yugang, TU Yanqiong, WANG Congqing, CHEN Juan, ZHANG Bohong. Network pharmacology and molecular docking to discuss the mechanism of Jinhutongdan prescription in the treatment of cholelithiasis and experimental verification [J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2022, 27(10): 1090-1098.