Abstract: AIM: To approach the protective effects of lignans in caulis Schisandra Chinensis on acute liver injure in rats induced by CCl₄.METHODS: By using the CCl₄ induced acute liver injury rat model, the effects of lignans in caulis Schisandra Chinensis on the levels of ALT and AST in serum and the contents of SOD, MDA and GSH-Px in liver homogenate, and the pathological change of liver tissue were observed.RESULTS: The lignans in caulis Schisandra Chinensis decreased the levels of ALT and AST in serum,decreased the content of MDA in liver homogenate,and increased the activities of SOD and GSH-Px. The pathological injury of liver could be obviously improved. The effect of anti-injury on liver of high dosage group was equal to that of bifendate positive group.CONCLUSION: Caulis Schisandra Chinensis has protective effect on acute liver injury of rats induced by CCl₄, and the mechanism is related to its antioxidant effect.

Key words: Caulis Schisandra Chinensis, Lignans, Carbon tetrachloride, Liver injury