Abstract: AIM: To observe the curative effect of ambrette capsule combined with tripterygium glycosides tablet on diabetic nephropathy.METHODS: 135 patients with diabetic nephropathy were randomly divided into combined group which was treated with traditional therapy including control blood glucose and control blood pressure with angiotensin Ⅱ receptor antagonist (ARB) and ambrette capsule 5 pieces three times a day by oral administration combined with tripterygium glycosides tablet 1 mg per day and per kilogram, ambrette group which was treated with traditional therapy and ambrette capsule 5 pieces three times a day and control group which was treated with traditional therapy .The 24 h urine protein quantitation, blood albumin, renal function, hepatic function, blood fat and blood routine were respectively detected and compared before treatment and after treatment for two, four, eight and twelve weeks.RESULTS: After 4 weeks treatment, combined group had significantly decreased the urine protein quantitation (P<0.01), but ambrette group had significantly decreased until 8 weeks treatment(P<0.01), there was no statistical significance in control group after 12 weeks treatment(P＞0.05). After 12 weeks treatment, there was significant difference in the urine protein quantitation among ambrette group, combined group and control group respectively (P<0.05 and P<0.01). There was no statistical significance on the other indexes(P＞0.05).CONCLUSION: Ambrette capsule or tripterygium glycosides tablet can decrease urine protein and postpone progress of renal function, but combined group had better curative effect and can shorten course of treatment.

Key words: Ambrette capsule, Tripterygium glycosides tablet, Diabetic nephropathy  ,  ,  ,  ,