Abstract: AIM: To evaluate the clinical efficacy of edaravone injection in patients with acute ischemic stroke.METHODS: A multicenter, randomized, double blind, placebo controlled, parallel and combined with basic medicals trial was carried out on patients with acute ischemic stroke. Beside the basic treatments,the patients in treatment group were received edaravone 20 mg dissolved in sodium chloride injection 100 mL,twice a day, for 14 days, while that of control group were received similar quantity of sodium chloride injection with those of edaravone group but without edaravone.RESULTS:Two hundred and thirty eight patients were enrolled in the study,119 in edaravone group and 119 in control group. The edaravone group had a better neurological deficits grade than control group from d7 and it had significant differences in statistics(P<0.01), and as time going, the difference become more significant.CONCLUSION: Edaravone injection is a new and efficient medicine in treatment of acute ischemic stroke.

Key words: Earavone injection, Free radical scavenger, Acute ischemic stroke, Phase II clinical trial