Abstract: AIM: To investigate the effects of fluvastatin on myocardial ischemia induced by exercise testing in patients with stable exertional angina pectoris and hypercholesterolemia.METHODS: Ninety patients with stable exertional angina pectoris, positive exercise test and hypercholesterolemia were randomly divided into a 12-week treatment period either diet plus fluvastatin (n=45) or diet alone(n=45). All the patients underwent exercise testing before and after the treatment period.RESULTS:Fluvastatin -treated patients had a significant decrease in total cholesterol, triglyccrides, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol after treatment(P<0.05). After treatment, the patients in the fluvastatin group had significantly increase in exercise tolerance, longer time in ST depression of 1.0 mm and decrease in the severity of ST depression.CONCLUSION: Fluvastatin can reduce exercise-induced myocardial ischemia in patients with stable exertional angina pectoris and hypercholesterolemia.

Key words: Fluvastatin, Angina pectoris, Exercise test, Hypercholesterolemia