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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2011, Vol. 16 ›› Issue (3): 270-273.

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Effect of allicin on macrophages of the immunosuppressed mice infected by candida albicans

HU Guo-wei, DONG Qun   

  1. Department of Microbiology,Wannan Medical College,Wuhu 241002,Anhui, China
  • Received:2011-02-18 Revised:2011-03-09 Online:2011-03-26 Published:2011-05-18

Abstract: AIM: To study the effect of allicin on macrophage of immunosuppressed mice infected by candida albicans.METHODS: The mice were randomly divided into preventive group, treatment group and infection group. Three days before the experiment, cyclophosphamide(CY) was given to the mice only once via abdominal cavity with a dosage of 200 mg/kg. The preventive group mice were fed with allicin for 7 days, the other two groups were fed with normal saline; Followed, the solution of candida albicans was administered intravenously to the mice via lateral tail vein with the concentration of 2 ×107/mL in the 8th day. At the same time, the preventive group and the treatment group were fed with allicin for 7 days, the infection group were fed with normal saline; 7 days later, the mice peritoneal macrophages of the three groups were collected.The cultural liquid of macrophages was prepared and the levels of NO and IL-12 were measured.RESULTS: Compared with the infective group, allicin could improve the levels of NO and IL-12 produced by the macrophage in abdominal cavity of mice in the preventive group and the treatment group.CONCLUSION: Allicin can improve the funetion of macrophage in the model mice infected by candida albicans.

Key words: Candid albicans, Allicin, Macrophage, IL-12, NO

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