Abstract: AIM: To observe 0.1% benzalkonium bromide solution on the prevention and treatment of skin wound healing and scar treatment.METHODS: 974 cases of trauma were randomly divided into treatment group and control group each for 487 cases. 0.5% of the complex with iodine solution was used for skin disinfection. 3% hydrogen peroxide solution, 0.9% sodium chloride injection, 0.1% benzalkonium bromide solution were continuously used to clean the wound. The 0.1% benzalkonium bromide solution was wet compressed after suture with bandage wounds, once every 2 days to wound healing in treatment group. 3% hydrogen peroxide solution and 0.9% sodium chloride injection were used to clear the wound in the control group, then bandage usually.The long-term healing scar of two groups were observed.RESULTS: The Vancouver scar scale of two groups had significantly difference in 12 months after skin wound healing, the treatment group was lower.CONCLUSION: 0.1% benzalkonium bromide solution has preventive effect on the skin and scar formation after wound healing.

Key words: Benzalkonium bromide , Skin, Healing scar