Usage of equivalent numerical method based on entropy weight in evaluating comprehensively the promoting effect of transdermal enhancers

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2011, Vol. 16 ›› Issue (4): 417-422.

Previous Articles Next Articles

Usage of equivalent numerical method based on entropy weight in evaluating comprehensively the promoting effect of transdermal enhancers

LI Zhi-ping¹, LIN Yan-qiong²,WANG Hui², LIANG Qing¹

¹Pharmacy Department of Guangdong Provincial Center for Skin Disease and STD Control, Guangzhou 510500,Guangdong,China;
²Chinese Medicine Pharmacology Staff Room of Guangdong Pharmaceutical University,Guangzhou 510006,Guangdong, China

Received:2011-03-14 Revised:2011-03-21 Published:2011-06-22

Abstract

Abstract: AIM: To investigate the use of equivalent numerical method based on entropy weight in evaluating comprehensively the promoting effect of transdermal enhancers. METHODS: Using paracetamol as model drug, the promoting effects of azone, menthol, camphor, oleic acid, clove oil, nepeta oil, patchouli oil were detected by transdermal absorption experimentation in rabbit skin in vitro, indexes such as cumulative permeation quantity, penetrating rates, enhancement ratio and lag time were calculated, finally the equivalent numerical method based on entropy weight was used to evaluate the promoting effects of those transdermal enhancers. RESULTS: The promoting effect of 2% camphor and 2% cloves promoted paracetamol was best, 1% Azone, 2% nepeta oil, 2% menthol, 2% oleic acid in sequence,2% patchouli oil was worst. CONCLUSION: The equivalent numerical method based on entropy weight could evaluate the promoting effect of transdermal enhancers objectively and fairly.

Key words: Entropy weight, Equivalent numerical method, Transdermal enhancer, Promoting effect

CLC Number:

LI Zhi-ping, LIN Yan-qiong,WANG Hui, LIANG Qing. Usage of equivalent numerical method based on entropy weight in evaluating comprehensively the promoting effect of transdermal enhancers[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(4): 417-422.

References

[1] 陈艳芬,王同任,王晖,等.主成分分析法对促透剂促透效果的评价[J].中国临床药理学与治疗学2010,15(7):788-793.
[2] 沈非沉,王晖,郭源源,等.几种促透剂联合使用对双氯芬酸钠体外经裸小鼠皮肤吸收的影响[J].数理医药学杂志,2007,20(3):362-363.
[3] 王晖,李昕,许碧莲,等.灰关联聚类法对几种促透剂促透效果的综合评价[J].中国中药杂志,2004,29(5):417-419.
[4] 许碧莲,王晖,许卫铭.新灰色关联分析法对促透剂促透效果的综合评价[J].时珍国医国药,2006,17(6):999-1001.
[5] 秦志斌,边耀璋,李宇峙.等效数值评价法用于交通大气质量评价[J].环境工程,2006,24(2):68,24.
[6] 李凡修,陈武,肖遥.等效数值模型用于污水综合排放级别划分研究[J].环境保护科学,2000,26(5):14-15.
[7] 纪桂霞.大气环境质量的等效数值评价法[J].环境工程,1999,17(6):58-59.
[8] 许卫铭,王宗锐,刘刚,等.一种高效率的药物透皮吸收试验装置的改进[J].中国药理学通报,1997,13(2):185-188.
[9] Jaymin CS, Idris K, Srinivas T, et al. Analysis of percutaneous permeation dataⅡ:Evaluation of the lag time method[J].Int J Pharm,1994,109(3):283-290.
[10] Gao S, Singh J. Mechanism of transdermal transport of 5-fluorouracil by terpenes:carvone,1,8-cineole and thymol[J].Int J Pharm,1997,154(1):67-77.
[11] Williams AC, Barry BW. Terpenes and the lipid-protein-partitioning theory of skin penetration enhancement[J]. P harm Res,1991,8(1):17-20.
[12] 许丽忠,张江山,王菲凤.熵权多目标决策环境监测优化布点模型及应用[J].环境工程,2007,25(1):61-63.
[13] 刘煜,郑恒.基于熵的新产品开发决策方法[J].科技进步与对策,2007,24(2):155-157.
[14] 陈守煜.防洪调度多目标决策理论与模型[J].中国工程科学,2000,2(2):47-52.
[15] 邹进,张勇传.一种多目标决策问题的模糊解法及在洪水调度中的应用[J].水利学报,2003,(1):119-122.
[16] 霍映宝,韩之俊.基于熵原理的上市公司综合评估研究[J].运筹与管理,2004,13(2):118-121.
[17] 楼成君,陈有才,吕有名.熵权多目标决策法在水资源系统决策分析中的应用[J].浙江水利科技,2005,(1):20-22.
[18] 朱福元.熵与信息论[J].自然杂志,1992,15(3):187-188.

Usage of equivalent numerical method based on entropy weight in evaluating comprehensively the promoting effect of transdermal enhancers

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 1

Recommended Articles

Metrics

Comments