Drug-drug interaction mediated by UGT

Abstract

Abstract: Glucuronidation catalyzed by UDP-glucuronosyltransferase (UGT) is often recognized as the main pathway of conjugative metabolism for a variety of endogenous substances and exogenous compounds. For the development of new drugs, the investigation of drug metabolism mediated by UGT and the evaluation of potential drug-drug interaction are essential. Drug-drug interactions have been extensively studied and attracted much attention from researchers worldwide. However, the area of drug-drug interaction mediated by UGTs has received less attention than CYPs. Therefore, it is important to enhance our understanding of the role UGTs play in metabolic drug interactions in light of the fact that many drugs and their metabolites undergo UGT-mediated conjugation reactions. This review summarizes latest studies of the drug-drug interaction mediated by UGT inhibition.

Key words: UGT, Inhibition, Interaction

CLC Number:

R969

ZHANG Yan, HAO Hai-ping, WANG Guang-ji. Drug-drug interaction mediated by UGT[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(4): 447-454.

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