Endogenous sleep-promoting substances

Abstract

Abstract: Sleep-wake cycle is regulated by humoral and neuronal mechanism, as well as circadian rhythm. Kuniomi Ishimori and Henri Piéron provided the first experimental evidence for chemical factors that presumably accumulate in the cerebrospinal fluid in dogs after sleep deprivation, and eventually induce sleep. These substances are named hypnotoxin. Accumulated findings show that these endogenous substances include prostanoids, nucleotides, cytokines, neuropeptides, hormones, amine derivatives, nitrogen oxide and so on. This paper presents an overview of current knowledge about the roles of endogenous sleep-promoting substances in the sleep-wake regulation with a focus on prostaglandin D₂, adenosine, interleukin-1, and tumor necrosis factor.

Key words: Endogenous sleep-promoting substances, Prostaglandin D₂, Adenosine, Cytokines

CLC Number:

R338.63

YUE Xiao-fang, QIU Mei-hong, QU Wei-min, HUANG Zhi-li. Endogenous sleep-promoting substances[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(6): 672-678.

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