Efficacy of epidural anesthesia combined with dexmedetomidine on visceral traction response during appendectomy

Abstract

Abstract: AIM: To evaluate the efficacy of epidural anesthesia versus intravenous dexmedetomidine on visceral traction response during appendectomy.METHODS: Eighty adult patients, American Society of Anesthesiology(ASA) physical status class Ⅰ-Ⅱ, undergoing appendectomy during epidural anesthesia were divided randomly into two groups that received 1 μg/kg dexmedetomidine (Dexmedetomidine Group) and the same volume normal saline(Control Group) intravenously for 10 min respectively. The visceral traction response of the patients, the changes of the MAP, HR and SpO₂, and the grade of Ramsay before and after dexmedetomidine or the normal saline was administered were evaluated during the operation.RESULTS: Intravenous dexmedetomidine could inhibit the visceral traction response during appendectomy, was superior to normal saline(P<0.01). The changes of MAP and SpO₂ in the two groups were not different, but HR was decreased significantly in Dexmedetomidine Group (P<0.01), the grades of Rassmay were increased significantly in Dexmedetomidine Group (P<0.01).CONCLUSION: Intravenous dexmedetomidine could inhibit the visceral traction response effectively during appendectomy.

Key words: Dexmedetomidine, Appendectomy, Ecphyadectomy, Visceral traction response

CLC Number:

R971⁺.2

CHEN Gong-jin, OU-YANG Bao-yi. Efficacy of epidural anesthesia combined with dexmedetomidine on visceral traction response during appendectomy[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2011, 16(8): 912-915.

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