Abstract: AIM: To compare bromocriptine in the treatment of pituitary prolactin micro-adenoma and the clinical effect of large adenomas.METHODS: There were sixty cases with pituitary prolactin micro-adenoma and 30 cases with large adenoma. Two groups were orally administered bromocriptine, the amount of night began with 1.25 mg, increased 1.25 mg every 3 d, until 2.5 mg, tid. The serum prolactin and pituitary magnetic resonance were detected before treatment and 28 weeks after treatment.RESULTS: The serum prolactin level decreased significantly in the same gender group (P<0.01) of the two groups after 28 weeks treatment than before treatment. The serum prolactin level in micro-adenoma group returned to normal, while those in large adenoma group both men and women remained above normal. There were significantly differences between the same gender before and after treatment of the prolactin level in the two groups (P<0.05). After 28 weeks, prolactin pituitary micro-adenoma cure rate was 16.67%, total effective rate was 75%, while non-pituitary prolactin macro-adenoma group found that the tumor disappeared, the total efficiency was only 46.67%.CONCLUSION: Bromocriptine treatment of pituitary prolactin micro-adenoma can return serum prolactin to normal level, pituitary prolactin adenomas shrink or even disappear; while prolactin macroadenoma should adopt comprehensive treatment model, such as drugs or surgery combined with radiation therapy.

Key words: Bromocriptine, Pituitary prolactin big-adenoma, Pituitary prolactin micro-adenoma