Abstract: AIM: To research the effect of Sanqitongshu capsule on expressions of serum level of IL-1β and IL-8 of patients with the intra-and extra-cranial arteriostenosis after stent-assisted angioplasty.METHODS: Patients were randomly divided into two groups: Sanqitongshu capsule group and control group. The serum level of IL-1β and IL-8 in during different phases (before and 1 h, 1, 3, 7 d after stent-assisted angioplasty) were detected with ELISA.RESULTS: There were significant differences in the levels of serum IL-1β and IL-8 among the 5 time points using one-way ANOVA(F value=21.03, 24.813 respectively)(P＝0.0001). IL-1β, IL-8 began to increase 1 h after the operations and reached the maximal value 24 h later. We also found significant differences in the levels of serum IL-1β and IL-8 between 1 d after the operation and the remaining time points (P＜0.05). The serum 1evel of IL-1β and IL-8 were significantly decreased in Sanqitongshu capsule group contrasted with the control group in 3 d, 7 d after operation (P<0.05).CONCLUSION: Serum 1evels of IL-1β and IL-8 increases markedly in patients with the intra- and extra-cranial arteriostenosis after stent-assisted angioplasty. Sanqitongshu capsule can decrease the expressions of IL-1β and IL-8 in the early period and reduce the inflammatory reaction of cerebral ischemia cascade reaction effectively.

Key words: Sanqitongshu capsule, Intra-and extra-cranial arteriostenosis stent-assisted angioplasty, IL-1β, IL-8