Domestic clinical research progress of photosensitive anticancer drugs

Abstract

Abstract: Photodynamic therapy has been commonly applied to the treatment of cancer among the national major hospitals, and the effect is obvious. As the center element of the photodynamic therapy, the research results of photosensitive drugs have also gained particular attention. This article begins with the introduction of photosensitive drug, tells the mechanisms of the photosensitive drug, and emphatically reviews the domestic clinical application in the therapy of photosensitive drugs on tumors in recent years.

Key words: Photosensitive drugs, Photodynamic therapy, Tumor, Mechanism of action, Clinical applications

CLC Number:

WANG Zi-hao, WANG Xue-feng, JIANG Han, WANG Jina-dong, SHI Wei-bin. Domestic clinical research progress of photosensitive anticancer drugs[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(1): 107-111.

References

[1] Lovell JF, Liu TW, Chen J, et al. Activatable photosensitizers for imaging and therapy[J].Chem Rev, 2010,110(5):2839-2857.
[2] Pervaiz S, Olivo M. Art and science of photodynamic therapy[J]. Clin Exp Pharmacol Physiol,2006,33(5/6):551-556.
[3] 瞿燕,韩光范.光动力学疗法治癌光敏剂的研究进展[J].中国激光医学杂志,2005,15(1):48.
[4] Huang Z. A review of progress in clinical photodynamic therapy[J]. Technol Cancer Res Treat,2005,4(3): 283-293.
[5] Josefsen LB,Boyle RW. Photodynamic therapy and the development of metal-based photosensitisers[J]. Met Based Drugs , 2008:276109.
[6] 高社干,魏洛霞,王立东,等.肿瘤光动力治疗的研究现状与展望[J].郑州大学学报:医学版,2008,13(3):405-410.
[7] 张丹萍,陈志龙,杨晓霞,等.光动力药物的研究与开发[J].药学进展,2007,31(12):529.
[8] Nowis D,Makowski M,Stoklosa T, et al.Direct tumor damage mechanisms of photodynamictherapy[J] Acta Biochim Pol,2005,52(2):339-352.
[9] 王洪武.光动力治疗肿瘤[J].医学研究杂志,2007,36(2):11.
[10] 李东红.卟啉类光敏剂药物运载体系的研究进展[J].肿瘤研究与临床,2007,19(1):66.
[11] 陈涛,吴超,傅经国,等.光敏剂辅助的光动力治疗[J].世界最新医学信息文摘,2004,3(1):976.
[12] 叶春祥,路睿.肿瘤光动力治疗研究进展[J].青岛医药卫生,2009,41(4):293.
[13] 禹丽娜,汲振余,赵立群,等.凋亡相关基因 p 53,Fas蛋白在早期食管癌及癌病变中的表达与 PDT疗效的关系[J].中国激光医学杂志,2005,14 (4):2 6.
[14] Antonsson B, Martinou JC. The Bcl-2 protein family [J].Exp Cell Res,2000,256(1):50-57.
[15] 李冠杰,侯晓强,焦岳超.光动力疗法诱导肿瘤细胞凋亡的研究进展[J].医药论坛杂志,2007 28(23):125.
[16] 乔亮.光动力疗法治疗进展[J].中国厂矿医学,2009,22(2):221.
[17] 黄正,强永刚,陈伟.光动力学疗法诱导抗肿瘤免疫反应研究的进展[J].中国激光医学杂志,2006,15:121.
[18] 葛海燕.光动力治疗消化系肿瘤的进展与展望[J].世界华人消化杂志,2008,16(5):457.
[19] 周传农.光动力医学的进展与前景[J].解放军医学杂志,2003,18(8)(增刊):S38-S40.
[20] 赵俭昌,姚瑞,郑颖娟.光动力治疗中晚期食管癌25例[J].实用医药杂志,2006,23(11):1343.
[21] 陈伙辉,汪森明,陈燕武,等.动力治疗梗阻性食管癌117例近期临床疗效分析[J].中国现代药物应用,2009,3(4):75.
[22] 张焕波,肖哲.光动力疗法治疗颅内肿瘤的研究进展[J].汕头大学医学院学报,2010,23(1):61.
[23] 董齐,李立,崔建春,等.光动力疗法在乳腺癌综合治疗中的应用[J]. 现代肿瘤医学,2008,16(4):581.
[24] 曾霞波,夏新蜀,余和平,等.光敏化姜黄素对人乳腺癌细胞的抑制作用[J].激光杂志,2008,29(2):81.
[25] 陈广幸,李章生,汪森明,等.光动力治疗中晚期中央型肺癌的临床初探[J].基础临床研究,2005,23:1977.
[26] 尚立群,周乃康, 顾瑛,等.竹红菌乙素-光动力疗法对比杀伤经顺铂诱导耐药及非耐药肺癌细胞系的实验研究[J].海军总医院学报,2006,19(2):68.
[27] 方杰,方祖军,张元芳.CDHS 80在光动力学治疗膀胱癌中的有效性和安全性研究[J].上海医学,2003,26(5):306.
[28] 易运连,朱武.5-氨基酮戊酸光动力疗法治疗皮肤癌及癌前病变的临床疗效分析[J].临床皮肤杂志,2010,39(1):57.
[29] 陈章,林珍,黄钢,等.光动力治疗恶性肿瘤27例临床疗效分析[J].西南国防医药,2008,18(6):854.
[30] 陈宏炜,陈锦灿,陈耐生,等.带有功能性多肽的光敏剂及其应用[J].生物化学与生物物理进展,2009,39(9):1106.
[31] 苗培田.光动力联合化疗治疗肿瘤的机制及进展[J].国际肿瘤杂志,2010,37(5):361.