Development of drugs targeting beta-amyloid for Alzheimer's disease

Abstract

Abstract: Alzheimer's disease (AD) is a neurodegenerative disease,which is clinically characterized by progressive cognitive decline and the decrease of the behavior and social adaptation ability. Because of the complicated pathogenesis of AD, effective anti-AD drug are very limited in clinical therapy. Growing evidence shows that accumulation of Aβ in the brain is the primary cause of AD and proposes that Aβ could be an important target for anti-AD drugs. This article reviews the latest development of drugs targeting Aβ to treat AD.

Key words: Beta-amyloid, Alzheimer's Disease, Development

CLC Number:

R741

REN Hong, LIAO Hong. Development of drugs targeting beta-amyloid for Alzheimer's disease[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(10): 1172-1178.

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