Effects and mechanisms of metformin on lifespan extension

Abstract

Abstract: A research of pharmacological intervention that decreases the rate of organism aging to extend their life span is a perspective direction. Several studies have shown that metformin which is a biguanide class drug used in the treatment of type 2 diabetes mellitus can slow down aging and prolong life span.The possible mechanisms may be related to AMPK activation, mTOR inhibition and its downstream molecules.This review describes the effects of metformin on lifespan extension in nematode, transgenic mice , rats and potential mechanisms.

Key words: Metformin, Lifespan extension, Mechanisms

CLC Number:

QI He, LIU Ting-ting, LI Guo-rong. Effects and mechanisms of metformin on lifespan extension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(11): 1295-1301.

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