Abstract: AIM: To evaluate the efficacy and safety of fudosteine in the acute exacerbation of chronic obstructive pulmonary disease( AECOPD). METHODS: 100 patients diagnosed as AECOPD were randomly divided into either therapy group and control group. Antibiotics, oxygen, bronchodilators, etc were used in two groups. At the same time the therapy group was given oral fudosteine 400mg three times daily, and the control group was given oral mucosolvan 60mg three times daily. Then the clinical efficacy and safety in two groups of patients were observed and analyzed. RESULTS: The response rate (RR) of clinical composite efficacy in the therapy group was significantly higher than that in the control group (86% vs 68%, P<0.05), and there was no significantly difference between the two groups of the safety (P>0.05). CONCLUSION: Fudosteine tablet is effective and slight side-effect used in AECOPD and should be used as a routine.

Key words: Fudosteine, Acute exacerbation of chronic obstructive pulmonary disease, Adverse effect