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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2012, Vol. 17 ›› Issue (8): 878-883.

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Study on the hemolysis causes of aminomethyl benzoic acid (PAMBA) injection

PAN Wei-song1, ZHOU Yong-biao1, ZHANG Ne-min1, XIAO Ying2,3   

  1. 1Institute for Drug Control of Guangzhou,Guangzhou 510160,Guangdong,China;
    2College of Pharmacy, Ji'nan University,Guangzhou 510632,Gungdong,China;
    3Key Lab of Guangdong College for TCM Bioactivity Material Foundation and Brand New Drug Research,Ji'nan University,Guangzhou 510632,Gungdong,China
  • Received:2012-02-27 Revised:2012-05-25 Online:2012-08-26 Published:2012-08-14

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Abstract: AIM: To study the hemolysis causes of the aminomethyl benzoic acid injection.METHODS: According to the hemolysis test, pH determination and Moore osmotic pressure test method in Chinese Pharmacopoeia 2010, to study the possible hemolysis causes.RESULTS: The hemolysisi causes is related to the pH value, and is not related to the Moore osmotic pressure.CONCLUSION: The pH value of the PAMBA injection should be determined to 4.3 to 4.5 to avoid hemolysis reaction.

Key words: PAMBA injection, Hemolysis reaction, pH, Adverse reaction

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