The inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2012, Vol. 17 ›› Issue (9): 978-982.

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The inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10

CHEN Li¹, ZHANG Jian², WANG Si-ying¹, HUANG De-wu¹, GU Wei-wang²

¹Laboratory Animal Center,Anhui Medical University,Hefei 230032, Anhui,China;
²Laboratory Animal Center&Department of Comparative Medicine, Southern Medical University, Guangzhou 510515, Guangdong,China;

Received:2011-12-27 Revised:2012-08-02 Published:2012-09-25

Abstract

Abstract: AIM: To investigate the inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10. METHODS: B16-F10 cells were injected into the tail veins of C57BL/6 mice to establish an experimental lung metastasis model, and the effect of juglone on lung metastasis was observed.RESULTS: The number of metastases in the animals that were given juglone 4.5,3,1.5 and 7.5 mg·kg^-1·d^-1 was significantly reduced as compared with the vehicle control(P<0.05),and the inhibition rates were 27.30%, 55.35%, 31.52%, 25.34%, respectively.Compared with the positive control group, the inhibitory rate of 3 mg/kg juglone was no significant difference (P>0.05). CONCLUSION: Juglone could inhibit melanoma metastasis of B16F10.

Key words: Juglone, B16F10 cell, Hematogenous metastasis

CLC Number:

R965.2

CHEN Li, ZHANG Jian, WANG Si-ying, HUANG De-wu, GU Wei-wang. The inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2012, 17(9): 978-982.

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The inhibitory effect of juglone on the metastasis of skin melanoma cell line B16F10

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