Abstract: AIM: To study the clinical efficacy and adverse reaction of Yiqihuoxuezhuanggu Formula in Qi stagnation and blood stasis primary osteoporosis(PMO) patients.METHODS: In this trial, PMO patients were randomly assigned into two groups:Yiqihuoxuezhuanggu Formula group, Xianlinggubao group.Medicines were given for 12 weeks. Bone metabolism,DEXA scanning,adverse reaction and serum data were determined.RESULTS: Compared with the control group,the expression of BMD,1,25-(OH₂) D₃ and blood calcium in Yiqihuoxuezhuanggu Formula group were increased significantly,less adverse reaction(P<0.05).CONCLUSION: Yiqihuoxuezhuanggu Formula shows on a better treatment in Qi stagnation and blood stasis PMO patients, its mechanism may be related to decreasing the bone resorption and promoting the bone formation, thus preventing the bone mass loss.

Key words: Primary osteoporosis, Qistagnationandbloodstasis, Yiqihuoxuezhuanggu Formula, Adverse reaction