Efficacy and safety of gefitinib treated elded-patients with advanced non-small cell lung cancer

Abstract

Abstract: AIM: To investigate the effect and safety of gefitinib in elderly patients with non small cell lung cancer.METHODS: 34 elderly patients with non-small cell lung cancer treated with radiotherapy were selected as control group, and 37 patients treated with gefitinib 250mg per day were selected as observation group,then the total effective rate, disease control rates, incidence of adverse reactions and CA125,CEA,CA242 in serum of two groups were analysed and compared.RESULTS: The total effective rate and disease control rates of observation group were higher than that of control group,while the incidence of adverse reactions of two groups had no significant differences (P＞0.05) but observation group was lower. CA125,CEA,CA242 in serum were all lower than before of two groups significant differences after the treatment (P＜0.05), and observation group was lower but had no significant difference (P＞0.05).CONCLUSION: The effect and safety of gefitinib in elderly patients with non-small cell lung cancer was better,and incidence of adverse reaction was lower, that can obviously improve the quality of life for elderly patients.

Key words: Gifinitib, Elded, Non-small cell cancer, CA125, Adverse reactions

CLC Number:

R734.2

LI Su-xia, YANG Xiao-lei, CHEN Su-xiu, LIU Jie-fan, QUAN Shi-chao. Efficacy and safety of gefitinib treated elded-patients with advanced non-small cell lung cancer[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1410-1413.

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