Phosphodiesterases in the CNS:Implications in mood and cognitive disorders

Abstract

Abstract: Cyclic nucleotide Phosphodiesterases (PDEs) are the only known enzymes that catalyze the hydrolysis of cyclic AMP (cAMP) and cyclic GMP (cGMP) and thus are integral to the regulation of cyclic nucleotide signaling and cellular communication. PDE2 is a member of the super family and it is highly expressed in the limbic nervous system, including the amygdala, hippocampus, and hypothalamus, which are important for emotional and cognitive function. This review discusses the current state and future development in the burgeoning field of PDE2 in the central nervous system. It is becoming increasingly clear that PDE inhibitors have therapeutic potential for the treatment of neuropsychiatric disorders involving disturbances of mood, emotion, and cognition.

Key words: PDE2, cAMP, cGMP, CNS, Learning and memory, Anxiety and depression

CLC Number:

R741

YAN Wei, CHEN Ling, WANG Fei, LI Qing-yu, NIU Guo-zhong. Phosphodiesterases in the CNS:Implications in mood and cognitive disorders[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1424-1429.

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