Effects of the adenosine 2A receptor-epoxyeicosatrienoic acids pathway in the treatment of salt-sensitive hypertension

Abstract

Abstract: Activation of rat adenosine 2A receptors (A_2AR) increases epoxygenase activity and epoxyeicosatrienoic acids (EETs) levels. Since EETs have the abilities to dilate the renal vessels and prevent elevation of blood pressure, the adenosine 2A receptor-epoxyeicosatrienoic acids pathway (A_2AR-EETs pathway) is an antipressor. The experiments of the Dahl salt-sensitive (SS) rats and the Dahl salt resistant (SR) rats show that in the Dahl SR rats fed a high salt (HS) diet, elevations of adenosine levels and the renal response to adenosine increase epoxygenase activity and EETs levels, resulting in a greater renal vasodilator. In other words, the Dahl SR rats are able to upregulate the A_2AR-EETs pathway to regulate blood pressure during salt loading. However, the Dahl SS rats don't have the above-mentioned capabilities. Thus upregulating the A_2AR-EETs pathway in the inability of Dahl SS rats during salt loading may contribute to the treatment of salt-sensitive hypertension.

Key words: Adenosine 2A receptors, Epoxygenase, Epoxyeicosatrienoic acids, Salt-sensitive hypertension

CLC Number:

R544.1

WANG Lin, LU Li. Effects of the adenosine 2A receptor-epoxyeicosatrienoic acids pathway in the treatment of salt-sensitive hypertension[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(12): 1436-1440.

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