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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2013, Vol. 18 ›› Issue (5): 487-490.

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Nasal mucosa and mucociliary toxicity of intranasal administration of compound recipe diazepam

SHENG Ping1, ZHANG Rui-tao2, WANG Hui3, HUANG Zhao3, FU Xiao-hua1   

  1. 1The Second Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510300, Guangdong, China;
    2School of Medicine, Sanxia University, Yichang 443002, Hubei, China;
    3School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China
  • Received:2013-01-21 Revised:2013-04-29 Online:2013-05-26 Published:2013-05-22

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Abstract: AIM: To study the nasal mucosa and mucociliary toxicity of intranasal administration of diazepam and diazepam compounded with menthol.METHODS: The rabbit nasal mucosa model was established by nasal administration with diazepam and its compound recipe containing menthol for a week. Then we investigated the effects on cellular morphology of the nasal mucosa and its recovery after drug withdrawal.RESULTS: The results of histopathologic slide showed that the thickness of epithelial layers had no obvious change when the rabbit model had been applied with diazepam and its compound recipe for a week. After drug withdrawal, the injury of mucociliary was recovered to some extent.CONCLUSION: Diazepam, menthol and their compound recipe, after intranasal administration, have mild toxicity and the negative effect can be reversible on the nasal mucosa.

Key words: Diazepam, Menthol, Intranasal administration, Mucosa, Security

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