Expression and significance of TKTL1 in glioma

Abstract

Abstract: AIM: To investigate the expression and significance of TKTL1 in glioma.METHODS: Fifty-four gliomas were collected immediately after surgery together with six normal brain tissues. The expression of TKTL1 in fifty-four gliomas and six normal pituitary tissues in terms of the mRNA and protein levels were detected by Realtime-PCR, Western blot and Immunohistochemistry analysis.RESULTS: The expression of TKTL1 in all glioma tissues was higher than that in normal brian tissues by wester blot and Realtime-PCR analysis (P<0.01), the expression amounts of protein and mRNA in high-grade gliomas and low-grade gliomas respectively were significantly different (P<0.01).CONCLUSION: The results reveal that the expression of TKTL1 is closely correlated with malignant degree of glioma, which indicates the expression of TKTL1 is intimately correlated with occurrence and development of glioma. Detecting TKTL1 may be a vital index to predict prognosis of glioma.

Key words: TKTL1, Glioma, Prognosis

CLC Number:

R965.2

LI Shu, HONG Yun, ZHANG Gen-bao, YANG Shi-yong, ZHOU Yan-fang, TAO Bang-bao. Expression and significance of TKTL1 in glioma[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2013, 18(6): 638-642.

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